Significant Information, Contraindication, Dosage and Uses of Nuedexta

Nuedexta is a combination of quinidine and dextromethorphan. Quinidine affects how the heart beats and is prescribed in people with specific heart rhythm problems. Dextromethorphan affects the brain signals that helps trigger cough reflexes.

It is used as a cough suppressant.

It is usually prescribed to treat an involuntary outburst of laughing or crying in people with some neurological issues like amyotrophic lateral sclerosis or Lou Gehrig’s disease and multiple sclerosis. Other off-label uses of Nuedexta are for the treatment of patients with neurodegenerative diseases like Parkinson’s disease and dementia.

Significant information about the drug

You need to be aware that Nuedexta should not be used in patients with heart failure, a critical heart condition called atrioventricular block, not unless the patient has a pacemaker. The drug is also not recommended for patients with a history of high-priority heart rhythm problem or Long QT syndrome.

Another contraindication of this drug is if the patient is using an MAO inhibitor in the past two weeks. MAO inhibitor and Nuedexta can cause a dangerous drug interaction. Monoamine oxidase inhibitors include linezolid, phenelzine, isocarboxazid, rasagiline, tranylcypromine, selegiline or methylene blue injection.

It is also a contraindication for people that are taking quinidine, quinine, mefloquine or people with a severe medical condition that is caused by choosing one of these medications. Some drugs can interact with Nuedexta and should avoid using at the same time.

You need to ask your doctor about the medicines that you are taking as well as medications you need to start or stop when you are on a dextromethorphan-quinidine treatment. Nuedexta should also not used when the patient is taking quanine, quanidine or mefloquine.

Not only that, but the drug is also a contraindication for patients with any forms of allergic reaction or severe medical conditions that are caused by taking any of the medication mentioned above. Before undergoing dextromethorphan-quinidine treatment, you need to make sure that you are not allergic to quinidine or dextromethorphan.

You should also avoid this drug when you have the following medical conditions:

Prior history of Heart failure

Previous history of a life-threatening heart rhythm problem

Serious heart problem called atrioventricular block; unless the patient has a pacemaker

Prior history of Long QT syndrome

If the patient is taking quinidine, quinine or mefloquine

If you have used Monoamine oxidase inhibitors for the past 14 days, you need to wait at least 14 days before taking the drug if you are on MAO inhibitors

Low level of blood platelets in your body

Bone marrow suppression


Lupus-like symptoms, including fever, joint pains, cold feeling or numbness in your toes or fingers and headaches

Visit to know more about MAO inhibitors.

Some medicines can also cause dangerous and unwanted effects if they are used with Nuedexta. Your physician might need to change the patient’s treatment plan if you are using the following medications:

Amitriptyline, desipramine, clomipramine, fluoxetine, sertraline, paroxetine, venlafaxine and certain anti-depressant drugs


Heart failure medications like flecainide, amiodarone, propafenone, procainamide, flecainide and propafenone

Psychiatric disorder drugs like Haldol, chlorpromazine, perphenazine, quetiapine, pimozide, thioridazine and risperidone

To make sure that Nuedexta is safe to use, you need to tell your physician if you have the following conditions:

Electrolyte imbalance like a decrease in magnesium or potassium in your body

High blood pressure, heart problems or coronary heart disease

Any kinds of heart rhythm problems like a decrease in heartbeat

Myasthenia Gravis

Urination disorders like an obstruction in the kidney or bladder

Stomach or intestinal blockage

Food and Drug Administration Pregnancy Category C

There is no proof whether the drug can harm the unborn baby. Patients should tell the physician if they have plans to get pregnant or they are already pregnant when using this drug. There is also no proof whether the medication can be passed through the mother’s breast milk or if it can harm nursing babies.

How to take Nuedexta?

Like any medication, Nuedexta should be taken exactly how the doctors prescribed them. You need to follow the exact direction on the prescription, no over or under medicating or over-extending the recommended days of the treatment. Traditionally, the recommended dosage is one capsule per day for seven days.

After the first seven days, the dosage is increased to one tablet every twelve hours. You need to follow the doctor’s prescription to the letter. Don’t take more than two capsules per day. The drug can be taken even without food, but it is recommended to take at least a light meal before taking the medication. Make sure that your physician will regularly check your progress. It will help them determine the duration of your treatment as well as the dosage. You may also need a regular heart check-up using the ECG or EKG

For information about this medication’s dosage, uses and side effects, click here.

Other information

You need to remember to keep Nuedexta as well as other medications out of children’s reach. You also need to avoid sharing medications with other patients. The drug is only for patients with health conditions mentioned above. Before taking the medication, always check with your nearest hospital or health care providers to make sure that the information specified in this article applies to your conditions.

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